Lectures in Membrane Proteins

• Lecture 1. Mitochondrial membranes and chemiosmotic coupling. (Acrobat - .pdf)
• Lecture 2. Redox carriers. (Acrobat - .pdf)
• Lecture 3. Complex I. Structure and Function. Part 1 (Acrobat - .pdf)
• Lecture 4. Complex I. Part 2. Complete structure, including the hydrophobic domain. (Acrobat - .pdf)
• Lecture 5. Complex II and complex III Part 1. Structure and Function. (Acrobat - .pdf)
• Lecture 6. Complex III. The Q-cycle. (Acrobat - .pdf)
• Lecture 7. ATP Synthase. (Acrobat - .pdf)

References

• Nicholls DJ, Ferguson, SJ. Bioenergetics3. Academic Press/Elsevier Science 2002
• Molecular Biology of the Cell. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. 5th edition. 2007. Garland Science. 4th Edition online at NCBI...

Specialist web sites

• Complex I Home Page
• News on the 3D structure from the Complex I Home Page
• Complex II Home Page
• Complex III Home Page
• Cytochrome oxidase home page
• ATP Synthase

Broader interest

• Introduction to Protein Structure. 2nd edition. Carl Branden, John Tooze
• Lane N. Power, Sex, Suicide. Mitochondria and the Meaning of Life. Oxford University Press. October 2005
• Nick Lane home page. Author of Oxygen: The Molecule that Made the World (OUP 2002); Power, Sex, Suicide: Mitochondria and the Meaning of Life (OUP 2005); Life Ascending: The Ten Great Inventions of Evolution (Profile/Norton 2009)
• Ina Schuppe Koistinen
• Odra Noel
• Mitochondrial Proteome. Database for mitochondria-related genes, proteins and diseases
• Proteopedia. Including membrane proteins, for example, 1prc and 1jb0

Qo. The movie

• Qo.mov

Molecule of the Month

• ATP Synthase
• Bacteriorhodopsin
• Cytochrome bc1
• Cytochrome c
• Cytochrome c Oxidase
• Hydrogenase
• Mechanosensitive Channels
• Photosystem I
• Photosystem II
• Potassium Channels
• Sodium-Potassium Pump

Relevant papers. Please observe copyright

Key references

• Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus
• Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus pdf file
• The architecture of respiratory complex I
• Structure of the membrane domain of respiratory complex I
• Respiratory complex I: ‘steam engine’ of the cell?
• News and Views. Structural biology: Piston drives a proton pump
• Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I
• An atypical haem in the cytochrome b₆f complex
• Structure of the Cytochrome b₆f Complex of Oxygenic Photosynthesis: Tuning the Cavity
• An Electronic Bus Bar Lies in the Core of Cytochrome bc₁
• Cytochrome b₆f: Structure for signalling and vectorial metabolism
• The Q cycle of cytochrome bc complexes: A structure perspective
• Protein synthesis by isolated pea mitochondria is dependent on the activity of respiratory complex II
• The function of genomes in bioenergetic organelles
• Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine
• High-Speed Atomic Force Microscopy Reveals Rotary Catalysis of Rotorless F1-ATPase
• High-Speed Atomic Force Microscopy Reveals Rotary Catalysis of Rotorless F1-ATPase. Supporting Online Material
• Seeing a Molecular Motor at Work

Other sources

• Energy transduction anchors genes in organelles
• Power for life
• Chemiosmotic coupling: The Cost of Living Professor Peter Rich
• How did LUCA make a living? Chemiosmosis in the origin of life By Nick Lane, John F. Allen, William Martin
• Power Games By Nick Lane

Nobel prizes

• 1978 Chemistry Nobel Prize to Peter Mitchell
• 1988 Chemistry Nobel Prize to Johann Deisenhofer, Robert Huber and Hartmut Michel
• 1997 Chemistry Nobel Prize to Paul D. Boyer, John E. Walker and Jens C. Skou

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