Lectures in Membrane Biochemistry

• The endomembrane system - endocytosis and exocytosis (Acrobat, .pdf file)
• The endomembrane system - vesicular transport and protein trafficking (Acrobat, .pdf file)
• Transport across membranes 1 - Proteins (Acrobat, .pdf file)
• Transport across membranes 2 - Small molecules and ions (Acrobat, .pdf file)
• Mitochondria and chloroplasts - analysis of compartments (Acrobat, .pdf file)
• Bioenergetics (Acrobat, .pdf file)
• The respiratory chain and oxidative phosphorylation (Acrobat, .pdf file)
• Oxidative phosphorylation, respiratory control and the chemiosmotic hypothesis (Acrobat, .pdf file)
• ATP Synthase - Coupling ATPase (Acrobat, .pdf file)

Course web pages

Membrane Biochemistry web pages

General reference

Cell and Molecular Biology: Concepts and Experiments
Gerald Karp. Fifth Edition 2008. John Wiley & Sons Inc.

Please observe copyright on material incorporated into presentations linked from here.

Further reading

• Chemiosmotic coupling: The cost of living. By Peter Rich. (.pdf file, 80 kb)
• Power for Life. Review of Nick Lane's book "Power Sex Suicide...." (.pdf file, 416 kb)
• N,K-ATPase. Page of Mark Hilge at Protein Biophysics, Nijmegen
• ATP Synthase. Group Pages of John Walker at the MRC Mitochondrial Biology Unit, Cambridge

Animations

• The pump cycle of Na,K-ATPase. By Mark Hilge at Protein Biophysics, Nijmegen
• Animation. From Light to ATP. By O. Fritsche and W. Junge, University of Osnabruck. (.avi file, 17.7 mb)
• Molecular animations of ATP synthase. From the research group of John Walker at the MRC Mitochondrial Biology Unit, Cambridge
• Animation. Powering the Cell: Mitochondria. From BioVisions at Harvard University

Relevant Nobel prizes

• 1906 Nobel Prize in Physiology or Medicine to Camillo Golgi and Santiago Ramón y Cajal
• 1974 Nobel Prize in Physiology or Medicine to Albert Claude, Christian de Duve and George E. Palade
• 1978 Nobel Prize in Chemistry to Peter Mitchell
• 1988 Nobel Prize in Chemistry to Johann Deisenhofer, Robert Huber and Hartmut Michel
• 1997 Nobel Prize in Chemistry to Paul D. Boyer, John E. Walker and Jens C. Skou
• 1999 Nobel Prize in Physiology or Medicine to Günter Blobel
• 2013 Nobel Prize in Physiology or Medicine to James E. Rothman, Randy W. Schekman and Thomas C. Südhof

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